Amprilan yog ib hom tshuaj rau cov tib neeg mob plawv tsis ua hauj lwm.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Ramipril
ATX
C09AA05 - Ramipril.
Tso cov ntawv thiab cov nyob ua ke
Cov ntsiav tshuaj ua kom ncaj, oblong nrog kho ntug, dawb (1.25 lossis 10 mg txhua), xim daj (2.5 mg ib qho), pinkish (5 mg txhua) xim. Ntim rau hauv cov hlwv blooj ntawm 7 (hauv ib daim ntawv thawv ntawm 3, 6, 9 daim ntawv tuav) lossis 10 pcs. (Hauv lub thawv - 2, 4, 8, 12 lossis 14 daim ntaub nyias nyias).
Cov ntsiav tshuaj yog pluav, oblong nrog kho nrog ntug.
Ib chav tsev ntawm cov tshuaj muaj cov tshuaj nquag - ramipril 1.25 mg, 2.5 mg, 5 mg lossis 10 mg;
Ntxiv rau, cov ntsiav tshuaj muaj cov xim sib haum rau kev pabcuam:
- 2.5 mg - "PB 22886 daj";
- 5.0 mg - "PB 24899 liab dawb."
Pharmacological kev txiav txim
Tsim los ntawm kev cuam tshuam nrog kev cuam tshuam nrog hepatic biocatalysts, ramipril metabolite - ramiprilat - ua rau qeeb ntawm kev sib txuas ntawm ACE. Raws li qhov tshwm sim, vasodilating effect tshwm sim, ua rau muaj kev nce ntxiv hauv kev mob siab hauv cov ntshav ncig. Tus tsim metabolite pab txhawm rau txo kev cuam tshuam dav dav ntawm cov hlab ntsha txhaws thiab tsis ua rau lub raum ntshav khiav tsis zoo.
Nyob rau tib lub sijhawm, kev tsim cov prostaglandins nce. Qhov no ua rau muaj kev tsim ntau ntxiv ntawm nitric oxide hauv endotheliocytes, uas muab cov nyhuv cardioprotective.
Kev ruaj khov ntawm cov ntshav siab nce ntxiv yuav tshwm sim hauv 1-2 teev tom qab noj thawj feem ntawm cov tshuaj. Qhov kev cia siab tshaj plaws tshwm sim tom qab 3-6 teev thiab tseem nyob rau ib hnub. Cov nyhuv antihypertensive yog nce zuj zus, thiab tom qab 1 lub hlis ntawm kev siv nws muaj peev xwm nyob tau ntev. Nws tsis muaj qhov cim tseg thim rov qab, yog li ntawd, nrog rau qhov kev tso tseg sai sai ntawm kev siv, kev pheej hmoo nce ntshav ntxiv tsis tshwm sim.
Hauv cov tib neeg kev txom nyem los ntawm kev mob ntshav tawm, cov tshuaj no tuaj yeem txo qis kev txhim kho myocardial hypertrophy thiab vascular phab ntsa.
Hauv cov neeg muaj lub plawv tsis ua haujlwm ntev, nws pab txo cov kev tiv thaiv ua ntej thiab lub siab saib xyuas thiab ua kom lub plawv dhia tsis zoo.
Nrog rau cov nephropathy, nws pab ua kom qeeb ntawm kev tsim kho lub raum thiab ua rau txo qis qhov xav tau hemodialysis lossis hloov raum. Hauv thawj theem, nws txo qhov tshwm sim ntawm proteinuria.
Hauv cov tib neeg muaj kev pheej hmoo mob hlab plawv mob hnyav uas tsim los ntawm cov ntshav txhaws lossis ntshav qab zib, ramipril inhibits qhov tsim ntawm lub plawv tsis ua haujlwm. Minimizes pheej hmoo ntawm myocardial infarction thiab mob stroke.
Hauv cov neeg uas muaj mob plawv, qhov tshwm sim ntawm tsev kho mob yog txo 27%, thiab kev pheej hmoo ntawm kev tuag sai yog txo 31%.
Cov Tshuaj Pharmacokinetics
Tom qab noj, nws yog tam sim ntawd nqus los ntawm sab sauv lub plab zom mov. Kev sim ib txhij nrog cov zaub mov inhibits nws nqus, tab sis qhov no tsis cuam tshuam rau qhov zoo ntawm kev ua kom zoo.
Hloov hauv daim siab, ua rau ramiprilat thiab diketopiperazine. Qhov kev tso ntau tshaj plaws tshwm sim hauv 1-3 teev. Ua rau muaj kev tso zis thiab quav. Nrog lub raum tsis ua haujlwm ntxiv, lub sijhawm ib nrab kev tshem tawm ntawm cov tshuaj yuav siv sijhawm ntev dua. Tom qab dhau los ntawm ntau theem ntawm kev hloov pauv, tawm hauv lub cev nyob rau hauv ib hnub, tab sis qhov tsawg kawg ntawm cov tshuaj no tau kuaj pom tau txuas ntxiv rau 3-4 hnub.
Kev ntsuas rau siv
Pom zoo rau cov tsos mob:
- arterial kub siab;
- mob ntsws raum;
- kws kho mob ntshav qab zib thiab tsis mob ntshav qab zib nrog rau lub raum pathologies.
Amprilan yog kws kho rau muaj kev pheej hmoo siab plawv ntshav siab.
Tsis tas li ntawd, nws yog kws kho rau muaj kev pheej hmoo mob plawv thiab muaj cov myocardial infarction hauv anamnesis thiab tom qab percutaneous transluminal angioplasty thiab mob hlab ntsha o los ntawm kev sib txhom.
Cov Yuav Tsum Muaj
Nws yog txwv tsis pub siv rau hauv cov xwm txheej xws li:
- ib tug tsis qaug rau ramipril thiab biocomponents ntawm cov tshuaj;
- keeb kwm ntawm mob hlwb los yog qhov yuav ua rau nws arogenesis thaum siv ACE inhibitors;
- autosomal cov kab mob tseem ceeb los ntawm hypertrophy ntawm cov hlab ntsha ntawm lub plawv thiab lub raum ntshaus;
- ntsuas ntsuas ntshav tsis ruaj;
- ventricular lub plawv atherosclerosis disturbances;
- hemodialysis;
- cev xeeb tub thiab lactation.
Tsis txhob ua daim ntawv yuav rau menyuam yaus thiab tub ntxhais hluas hnub nyoog qis dua 18 xyoo.
Nrog saib xyuas
Kev ntsuas xws li:
- atherosclerotic qhov txhab ntawm txoj hlab ntshav leeg thiab ntshav hlab ntsha;
- cov tsos mob hnyav ntawm arterial hypertension;
- kev kho ua ntej nrog diuretics;
- lub plawv tsis ua hauj lwm, uas siv lwm cov tshuaj tiv thaiv kab mob siab;
- daim siab ua haujlwm;
- hloov raum;
- mob ntshav qab zib mellitus thiab qhov kev pheej hmoo ntawm kev tsim hyperkalemia;
- lub cev qhuav dej ntawm lub cev.
Nrog kev ceev faj, siv cov tshuaj rau daim siab ua haujlwm.
Nrog ceev faj yog kho rau cov neeg nyob laus.
Yuav ua li cas coj Amprilan
Sab hauv tsis ntxo. Kev teem caij thiab txhaj tshuaj rau ib cov tshuaj yog nqa los ntawm kws kho mob. Nyob ntawm tus mob ntawm tus neeg mob thiab qhov kev cia siab yuav ua kom tshwm sim. Lub chav kawm ntawm kev kho yog ntev thiab yuav tsum tau saib xyuas tas li los ntawm tus kws kho mob.
Yog tias mob ntshav dhau los: kev siv ib zaug ib hnub yog 0.0025 g. Yog tias cov nqis tes ua tsis ua haujlwm ntev li 3 lub lis piam, qhov ntau npaum li cas ob zaug. Maj mam, kev ua haujlwm ib zaug nce ntxiv rau qhov siab tshaj plaws txhua hnub ntawm 0.01 g. Cov kev xaiv ntawm kev kho yuav tuaj yeem koom nrog lwm cov tshuaj hauv pawg no.
Ntawm txoj kev pheej hmoo ntawm myocardial infarction, mob hlab ntsha tawg, lossis nrog kev hem thawj ntawm kev tuag, qhov nrawm nrawm niaj hnub noj yog 0.0025 g.
Thaum lub plawv tsis ua haujlwm: ib-zaug ib hnub yog 0.00125 g .Thaum kis tsis ua tiav, cov koob tshuaj yuav tsum maj ob npaug. Qhov ntim ntau tshaj plaws txhua hnub yog 0.01 g.
Thaum muaj mob ntshav qab zib / tsis mob ntshav qab zib nephropathy: tus qauv ib-zaug txhua hnub - 0.00125 g. Yog tias chav kawm tsis zoo - nce ntxiv rau 0.005 g.
Yog tias muaj kev pheej hmoo ntawm myocardial infarction, mob hlab ntsha tawg, lossis yog tias muaj kev pheej hmoo tuag, txoj kev noj tshuaj nrawm txhua hnub yog 0.0025 g .Tus ntxiv, kev ua haujlwm ib zaug nce mus rau qhov ntau tshaj txhua hnub ntau ntawm 0.01 g.
Noj cov tshuaj rau ntshav qab zib
Qhov pib txhua hnub ntawm ramiprilat yog 0.00125 g nrog maj mam nce mus rau 0.005 g.
Sab sij huam
Txoj kev kho mob pib nrog qhov pib ib zaug ib hnub ntawm 0.00125 g. Qhov cuam tshuam ntawm kev haus ntau tshaj 0.01 g tsis tau kawm hauv kev tshawb fawb tswj tau. Thaum siv kev kawm tiav me ntsis ntawm 0.00125 txog 0.01 g, tsis muaj peev xwm teb tau los ntawm lub cev tau.
Kev kho mob txoj hnyuv
Phenomena ntawm xeev siab, ntuav, raws plab los yog quav hnyuv, epigastric tsis xis nyob, nqhis dej, mob siab rau lub cev, thiab nce bilirubin concentration.
Ib sab tshuaj yog raws plab.
Hematopoietic plab hnyuv siab raum
Qee zaum cov cim ntawm agranulocytosis, erythrocytopenia, thrombocytopenia, hemoglobinemia, neutropenia, eosinophilia tshwm sim.
Nruab nrab hauv lub paj hlwb
Kev ua kom tsis muaj zog, nrog rau mob taub hau thiab tsaug zog, mob hlwb-hauv siab tsis zoo, tshee tshee thiab mob leeg.
Los ntawm cov leeg musculoskeletal
Cov tsos mob ntawm tus mob myositis, mob myalgia, mob pob qij txha, mob caj dab yog qee zaum tshwm sim.
Los ntawm lub tshuab ua pa
Dyspnea, qhov tshwm sim ntawm kev hnoos tsis txaus ntseeg.
Los ntawm genitourinary system
Exacerbation ntawm pathologies ntawm lub hlwb rov qab.
Los ntawm cov hlab plawv system
Cov cim ntawm kev mob siab, hypotension, tachycardia.
Txoj hlab plawv tuaj yeem pom cov cim ntawm hypotension.
Kev ua xua
Qhia tseeb ntawm cov tawv nqaij hloov pauv thiab dermatitis, angioedema.
Cov lus qhia tshwj xeeb
Xav kom muaj kev soj ntsuam ntawm tus neeg mob feem ntau. Yog tias pom tus mob SARS tshwm sim, sab laj nrog kws kho mob.
Cawv tau zoo
Txwv tsis pub koom cov cawv txuam nrog cov khoom. Nce cov nyhuv ntawm ethanol rau lub hauv nruab nrab hauv cov hlab hlwb txhaws.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Nrog ceev faj thaum ua cov haujlwm uas yuav tsum muaj kev saib xyuas. Nws yog qhov tsis xav tau tsav los yog kev ua haujlwm uas muaj qhov phom sij txaus ntshai.
Nws yog qhov tsis xav tau tsav los yog kev ua haujlwm uas muaj qhov phom sij txaus ntshai.
Siv thaum cev xeeb tub thiab lactation
Txhaum txoj cai tsim ntawm tus me nyuam. Nws yog txwv tsis pub rau thaum lactation.
Khaws Amprilan rau cov me nyuam
Hauv cov kev sim uas tswj tau, qhov ntxim rau cov menyuam yaus lub cev tsis tau kawm.
Siv rau lub sijhawm qub
Nrog ceev faj.
Hauv cov laus, siv cov tshuaj nrog ceev faj.
Daim ntawv thov rau lub raum khiav tsis zoo
Kev ua haujlwm siab tshaj plaws yog 0.0025 g.
Siv rau lub siab ua haujlwm tsis zoo
Nrog kev ua txhaum loj ntawm daim siab ua haujlwm, qhov kev ua haujlwm loj tshaj plaws yog 0.005 g.
Noj ntau dhau
Cov chaw kuaj mob: poob rau hauv cov ntshav siab rau theem tseem ceeb, mob raum tsis ua haujlwm.
Nrog rau kev mob hnyav tshaj plaws ntawm kev noj ntau dhau, yuav tsum tau pw hauv tsev kho mob ceev.
Kev cuam tshuam nrog lwm yam tshuaj
Kev siv ib txhij siv cov tshuaj los ntawm ntau tus NSAIDs tuaj yeem ua rau kev tsim lub raum kev ua haujlwm ntawm lub raum thiab ua rau kom muaj cov poov tshuaj nyob hauv lub cev.
Sodium ntsev txhawb nqa cov kev txuam nrog sodium hauv cov ntshav ntshav, uas ua rau cov khoom antihypertensive tsis muaj zog. Zoo sib xws, muaj kev nce estrogen hauv lub cev.
Kev siv cov tshuaj ib zaug uas txo cov ntshav siab yuav ua rau cov nyhuv tsis zoo.
Contraindicated kev sib txuas ua ke
Nws tsis yog ua ke nrog kev siv cov pa hluav taws xob tsis txaus cuam tshuam rau kev puas tsuaj thaum lub sijhawm hemodialysis.
Cov tshuaj tsis tau sau tseg nyob rau theem ntawm kev kho mob ntawm nephropathy.
Cov tshuaj tsis yog kws kho mob ua ke nrog Aliskiren rau ntshav qab zib mellitus lossis ua rau lub raum tsis ua haujlwm, nrog rau Dextran sulfate kom txo qis cov roj (cholesterol).
Tsis tas li ntawd, nws tsis yog kws kho rau theem ntawm kev kho mob nephropathy nrog glucocorticosteroids, immunomodulators thiab / lossis lwm yam cytostatic.
Tsis pom zoo kev sib txuas ua ke
Kev siv cov tshuaj muaj cov poov tshuaj muaj txiaj ntsig ua rau cov txuam nrog cov poov tshuaj.
Vasopressor sympathomimetics paug cov tsis zoo ntawm cov tawv nqaij ramipril.
Tej kev sib txuam uas xav tau ceev faj
Hauv kev sib xyaw nrog antihypertensives, diuretics, sedatives, tshuaj loog.
Nrog cov roj ntsha lithium - pab txhawb lawv cov kev ceev hauv tib neeg lub cev.
Nce hypoglycemic thaj chaw ntawm cov kua dej thiab cov tshuaj los ntawm sulfonylurea.
Kev sib xyaw ntawm ntau yam ACE inhibitors nrog ramipril provokes tsim ntawm angioedema.
Analogs
Amprilan ND muaj ntau qhov hloov pauv. Lawv yog cov zoo sib xws nyob rau hauv muaj pes tsawg leeg, tab sis txawv nyob rau hauv lub xub ntiag ntawm lub hauv paus pib tshuaj. Pom nyob hauv cov npe:
- Wazolong;
- Kev Kho Mob;
- Dilaprel;
- Ramigamma
- Ramilong;
- Ntse;
- Rampril;
- Pyramids;
- Huab Tais;
- Tritace ntxiv rau.
Ib qho ntawm cov qauv sib piv ntawm Amprilin yog Corpril.
Cov nyhuv xav pom zoo tuaj yeem tau txais tom qab siv ntawm Amprilan NL.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Los ntawm tshuaj.
Kuv tuaj yeem yuav yam tsis tas yuav tshuaj
Qee cov khw muag tshuaj hauv online tuaj yeem yuav tau tom tab laj muag.
Amprilan Nqe
Tus nqi nyob ntawm ntau tus naj npawb ntawm cov tshuaj hauv lub pob thiab qhov ntim ntawm cov tshuaj muaj feem tseem ceeb hauv lawv. Yog li, piv txwv, tus nqi nruab nrab ntawm ib pob muaj ntawm 30 ntsiav tshuaj nrog tshuaj ntawm ramipril 5 mg hauv cov khw muag tshuaj sib txawv ntawm 600 txog 900 rubles. Nyob rau tib lub sijhawm, tus nqi ntawm cov pob khoom zoo sib xws nrog tshuaj ntawm 1.25 mg yog nyob rau hauv nqe tus nqi li ntawm 260 txog 290 rubles.
Cia rau cov neeg mob rau cov tshuaj
Cia kub ntau yam - 0 ... + 25 + С. Nkaum ntawm cov menyuam yaus.
Hnub tas sij hawm
3 xyoos
Chaw tsim tshuaj paus
KRKA, Slovenia
Amprilan tshuaj xyuas
Cov kws kho mob thiab cov neeg mob qee zaum muab faib rau qhov ua tau ntawm ramipril. Feem ntau qhov no feem ntau vim yog siv tsis yog tus thawj cov tshuaj, tab sis nws cov generics.
Cov kws kho mob
Senkov G.N., kws kho plawv, Kemerovo
Kuv sau ntawv rau cov neeg mob uas muaj cim ntshav liab thiab lub plawv tsis ua haujlwm ntev. Kuv sau ob qho tib si monogamous thiab hauv tandem nrog lwm yam tshuaj. Cov koob tshuaj yog ib leeg rau txhua tus neeg mob. Tsis muaj kev tshwm sim tsis zoo nyob rau hauv kuv xyaum.
Kiryukhina I.D., kws kho plawv, Penza
Ramipril qhia tau nws tus kheej zoo hais txog kev ua kom lub ntshav khiav ceev thiab ua kom lub siab hloov kho. Kuv pom zoo nws mus rau cov neeg mob kev txom nyem los ntawm kub siab, mob hlab ntshav lossis ntshav qab zib. Nws muaj cov khoom zoo uas cuam tshuam zoo rau kev ua haujlwm ntawm lub raum thiab plawv. Yuav tsum siv ntau xyoo. Sab sij huam - qee zaum nws ua rau hnoos.
Cov neeg mob
Maria, 48 xyoo, Rostov-on-Don
Tau ntau xyoo, jumps hauv cov ntshav siab tau raug tsim txom - los ntawm kev phais mob ntawm urolithiasis. Tus kws kho mob tau sau cov tshuaj no. Pom zoo kom noj 1 lub tshuaj txhua 24 teev. Tab sis ntev mus kuv haus nws tsuas yog thaum kuv hnov qhov tsis zoo. Xyoo no, kev tawm tsam tau ua ntau dua, yog li tam sim no koj yuav tsum haus nws yuav luag txhua hnub. Tom qab li ib nrab ib teev, lub siab rov qab mus rau qub, tab sis hnoos tshwm.
Nikolay, 60 xyoo, Biysk
Qhov kev hais daws no tau raug tshuaj los ntawm cheeb tsam kws kho mob hauv kev txuas nrog kev kis mob ntshav nce siab. Thawj koob tshuaj yog 1.25 mg, tab sis tsis muaj qhov tshwm sim. Maj mam nce mus rau 5 mg. Tam sim no kuv xav zoo: Kuv haus 1 ntsiav tshuaj thaum sawv ntxov - thiab hnov qab txog lwm yam tshuaj rau tag nrho ib hnub. Siab tsis muaj leej twg thab ntxiv lawm.
