Tshuaj Aterocardium: cov lus qhia rau kev siv

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Aterocardium yog txhais tau tias txo qis platelet aggregation muaj peev xwm.

Lub Npe Tsis Yog Neeg Tsis Muaj Npe

Clopidogrel.

Aterocardium yog txhais tau tias txo qis platelet aggregation muaj peev xwm.

ATX

Qhov ATX code yog B01AC04.

Tso cov ntawv thiab cov nyob ua ke

Cov tshuaj muaj nyob hauv daim ntawv foos. Txhua lub ntsiav tshuaj muaj 75 mg ntawm cov tshuaj nquag - clopidogrel.

Cov ntsiav tshuaj yog zaj duab xis-txheej. Lawv muaj cov kab biconvex puag ncig thiab xim xim.

Pharmacological kev txiav txim

Pharmacological cov kev ua ntawm cov tshuaj yog txuam nrog kev xaiv inhibition ntawm kev khi ntawm adenosine diphosphate mus rau saum npoo receptors nyob ntawm platelets. Yog tias tsis muaj adenosine diphosphate, qhov kev ua haujlwm ntawm cov membrane protein ua lub luag haujlwm tseem ceeb rau cov txheej txheem ntawm kev sib sau ua ke ntawm cov ntshav cov ntshav poob qis.

Platelet aggregation yog inhibited tsis tsuas yog los ntawm thaiv qhov txuas ntawm ADP, tab sis kuj los ntawm lwm cov khoom siv uas koom nrog hauv ntshav coagulation. Txoj kev hloov ntawm daim nyias nyias ntawm cov ntshav plasmaets yog ib yam tsis hloov. Txhawm rau rov qab qib dhau los ntawm coagulability, platelet muaj pes tsawg leeg ntawm cov ntshav yuav tsum tau hloov tshiab.

Qhov kev txiav txim ntawm clopidogrel pib nrog thawj hnub ntawm kev siv. Muaj txuas ntxiv ntawm lub sijhawm los ntshav thiab hloov pauv hauv kev muaj peev xwm ntawm cov ntshav. Cov kev ua ntawm cov tshuaj tiv thaiv nquag hloov zuj zus nrog kev siv cov ntsiav tshuaj dua, ruaj khov rau 3-7 hnub.

Hauv qab ntawm Aterocardium, lub peev xwm ntawm platelets rau adhere poob ntau dua 50%.

Hauv qab ntawm Aterocardium, lub peev xwm ntawm platelets rau adhere poob ntau dua 50%. Kev kho kom tsis tu ncua ntawm qhov ntsuas no tshwm sim 4-6 hnub tom qab kawg ntawm kev kho. Tus nqi ntawm kev rov qab yog nyob ntawm hematopoietic kev ua haujlwm ntawm cov pob txha pob txha, uas yog lub luag haujlwm rau kev tsim cov ntshav ntshav tshiab.

Cov Tshuaj Pharmacokinetics

Nrog cov tshuaj ntawm qhov ncauj ntawm cov tshuaj hauv cov txheej txheem tshuaj (75 mg), nws nquag nquag nqus los ntawm plab hnyuv plab. Qhov siab tshaj plaws zoo ntawm cov khoom ua kom nquag plias hauv cov roj ntsha tau ua tiav hauv 0.5-1 teev. Lub bioavailability ntawm cov tshuaj yog nyob ntawm kwv yees li 50% ntawm kev noj tshuaj npaum li cas. Cov lus muab khi ntawm cov nquag tivthaiv nrog thauj peptides yog li ntawm 95% txog 99%. Cov qib ntawm khi ruaj khov yog nyob ntawm cov koob tshuaj siv thiab seem stably siab.

Kev hloov pauv hauv cov tshuaj tshwm sim nyob rau hauv kev cuam tshuam ntawm daim siab enzymes. Kev mob plab tshwm sim ob qho tib si vim isoenzymes ntawm cytochrome Z450, thiab vim yog lwm yam enzymes. Kev hloov tshuaj lom neeg ntawm clopidogrel tshwm sim nyob rau hauv ntau theem, qhov tshwm sim ntawm uas yog qhov tsim kom muaj cov nquag thiab tsis muaj zog metabolites. Thawj zaug tam sim ntawd tom qab tsim cov dej tsis tsim nyog khi rau lub chaw txais khoom ntawm cov ntshav ntshav, yog li txo cov ntshav coagulation.

Lub ntsiab isoenzyme koom nrog kev hloov pauv ntawm cov khoom nquag yog CYP2C19. Qhov tsim los ntawm kev ua kom nquag plias metabolite nyob ntawm cov qauv ntawm genotypic ntawm isoenzyme no. Muaj 8 ntawm nws cov alleles. Thawj ua tiav hloov clopidogrel, pab txhawb rau qhov siab tshaj plaws nyob rau hauv cov txheej txheem sib sau ua ke. Tus so tsis metabolize lub txuam yam nyob rau hauv tag nrho. Qhov feem ntau ntawm lawv yog 2 thiab 3 alleles.

Ib feem ntawm cov tshuaj tau tawm hauv lub cev los ntawm txoj hnyuv.

Kev ua tiav kev tshem tawm ntawm cov tshuaj muaj sia thiab nws cov khoom siv tshuaj tiv thaiv yuav siv 5 hnub. Los ntawm lub cev, cov tshuaj yog sib npaug ntawm ob sab raum thiab txoj hnyuv. Ib nrab-lub neej ntawm cov tshuaj yog 6-8 teev. Nws tsis yog nyob ntawm lub sijhawm kho.

Dab tsi pab?

Cuab tam yog raws cov ntawv hauv qab no:

  • atherothrombotic tso rau ntawm lub nkoj loj lossis txuas;
  • mob ntsws vwm sai nrog qhov pheej hmoo ntawm thrombosis;
  • cov neeg mob uas tau mob plawv lossis mob stroke;
  • rau kev tiv thaiv ntawm thrombotic txhaws ntawm cov hlab ntshav thaum lub sij hawm fibrillar mob ntawm lub atria.

Feem ntau sau tseg nyob rau hauv sib xyaw nrog acetylsalicylic acid. Ib qho kev sib thooj zoo sib xws yog tsim rau cov neeg mob lub plawv mob angioplasty.

Cov Yuav Tsum Muaj

Cov kev tsis sib haum xeeb rau kev teem caij clopidogrel yog:

  • ib tug neeg lub cev sib xyaw rau cov tshuaj nquag lossis lwm yam tshuaj;
  • mob siab rau daim siab hnyav;
  • sab nraud thiab sab hauv los ntshav;
  • lactase tsis txaus;
  • ulcerative tsis xws luag ntawm mucous daim nyias nyias nrog qhov kev pheej hmoo los ntshav.

Hauv kev mob siab rau hepatic kawg, kev haus yeeb tshuaj yog txwv.

Yuav ua li cas noj tshuaj Aterocardium?

Tus txheej txheem koob tshuaj ntawm cov tshuaj rau cov neeg laus yog 75 mg ib hnub ib zaug, tsis hais noj zaub mov dab tsi.

Hauv cov mob plawv mob sai uas tsis muaj ST ntu ntu, ib koob tshuaj 300 mg ntawm clopidogrel yog tshuaj. Kev kho mob txuas ntxiv nrog cov txheej txheem tshuaj. Tsis tas li ntawd, cov tshuaj acetylsalicylic acid yog qhov tsim kho, qhov ntau npaum ntawm tau txiav txim siab ib tus zuj zus. Nws tsis pom zoo kom noj ntau dua 100 mg ntawm acetylsalicylic acid ua ke nrog cov cuab yeej no. Qhov no tuaj yeem ua rau los ntshav. Lub sijhawm yam tsawg kawg nkaus ntawm kev kho mob yog 90 hnub. Nws raug nquahu kom txuas ntxiv txoj kev kho kom txog 1 xyoos.

Yog tias tus neeg mob tau nce siab hauv ntu Seem, cov kev siv tshuaj zoo ib yam. Cov neeg uas muaj hnub nyoog tshaj 75 xyoos yuav tsum tsis txhob tau txais qhov kev muab tshuaj tso thawj zaug. Cov neeg mob txog rau lub hnub nyoog no pib kho nrog 300 mg ntawm Aterocardium. Nrog rau tus kab mob no, kev kho mob ntev li 1 lub hlis, kev tsim nyog ntawm kev kho mob tsis tu ncua tsis tau kawm.

Rau kev kho mob ntawm atrial fibrillar kev mob plab, ib hnub txheem ib hnub ntawm cov tshuaj yog kws kho. Tsis tas li ntawd, cov tshuaj acetylsalicylic acid yog tau hais tseg.

Nrog ntshav qab zib

Cov neeg mob ntshav qab zib tau muab tshuaj ib yam li cov neeg noj qab haus huv. Cov tshuaj tsis cuam tshuam nrog cov tshuaj tiv thaiv kab mob los yog tshuaj insulin.

Kev phiv tshuaj ntawm Aterocardium

Ntawm ib feem ntawm cov plab hnyuv siab raum ntawm lub zeem muag

Los ntshav los ntawm cov hlab ntawm lub qhov muag tuaj yeem tshwm sim.

Xeev siab, ntuav - ib qho tshwm sim ntawm yeeb tshuaj.
Aterocardium tuaj yeem ua rau mob plab.
Kev ua mob ntawm cov txiav yog suav tias yog kev phiv los ntawm cov tshuaj Aterocardium.
Aterocardium tuaj yeem ua rau kiv taub hau.
Raws li kev noj cov tshuaj, qhov tshwm sim ntawm kev xav ua tus coj tus cwj pwm tsis txaus.
Mob taub hau yog suav hais tias yog kev phiv los ntawm cov tshuaj.
Aterocardium tuaj yeem ua rau pob ntseg pathologies.

Los ntawm cov leeg nqaij thiab pob txha sib txuas

Kev kho mob tuaj yeem ua kom nyuaj los ntawm kev tshwm sim ntawm cov ntshav hauv lub hnab ua ke, mob pob qij txha, mob caj dab, mob nqaij.

Kev kho mob txoj hnyuv

Cov kev mob tshwm sim nram qab no tej zaum yuav tshwm sim:

  • mob epigastric;
  • xeev siab
  • ntuav
  • los ntshav los ntawm lub nkoj ntawm cov qog ua kua;
  • mob caj dab;
  • plaub sua;
  • mob plab peptic;
  • hloov pauv ntawm qhov xwm ntawm rooj zaum;
  • mob plab
  • mob plab.

Hematopoietic plab hnyuv siab raum

Qhov pom tau:

  • thrombocytopenia;
  • leukopenia;
  • neutropenia;
  • thrombocytopenic purpura;
  • agranulocytosis;
  • anemia
  • eosinophilia;
  • pancytopenia.

Nruab nrab hauv lub paj hlwb

Tej zaum yuav teb rau kev kho mob los ntawm qhov pom ntawm:

  • Kiv taub hau
  • paresthesia;
  • mob taub hau;
  • saj kev cuam tshuam;
  • pathologies ntawm pob ntseg;
  • intracranial hemorrhage;
  • tsis nco qab zoo;
  • Cov tsos mob hallucinatory syndrome.
Aterocardium tuaj yeem ua pob.
Spasm ntawm cov leeg ntawm bronchi yog phiv los ntawm yeeb tshuaj.
Hypotension suav tias yog kev phiv los ntawm cov tshuaj Aterocardium.

Los ntawm cov kab mob zis

Muaj tshwm sim:

  • hematuria;
  • glomerulonephritis.

Los ntawm lub tshuab ua pa

Tej zaum yuav tshwm sim:

  • los ntshav los ntawm lub nkoj ntawm cov qog ua kua;
  • cov leeg txha caj qaum ntawm lub ntsws;
  • mob ntsws o.

Ntawm ib sab ntawm daim tawv nqaij

Qhov pom tau:

  • hemorrhages hauv qab daim tawv nqaij;
  • ua pob
  • eczema
  • dermatitis;
  • o tuaj;
  • cov phiaj xwm lichen;
  • purpura.

Los ntawm genitourinary system

Cov tshuaj tsis cuam tshuam rau kev muaj menyuam.

Los ntawm cov hlab plawv system

Tej zaum yuav tshwm sim:

  • los ntshav
  • hypotension;
  • hemorrhagic vasculitis.

Qhov tshwm sim ntawm tus kab mob siab yog suav tias yog kev phiv los ntawm cov tshuaj ...

Endocrine system

Cov cuab yeej tsis ua rau muaj kev hloov txawv txav hauv cov qib hormone lossis lwm yam kev ua haujlwm ntawm cov kabmob endocrine.

Ntawm ib sab ntawm daim siab thiab cov hnyuv

Tej zaum yuav tshwm sim:

  • kab mob siab;
  • Neeg Raug Ntse;
  • nce kev ua haujlwm ntawm daim siab enzymes.

Los ntawm ib sab ntawm cov metabolism

Yuav ua rau kom muaj creatinine ntau ntxiv hauv cov hlab ntshav.

Kev ua xua

Tej zaum yuav tshwm sim:

  • kev siv tshuaj anaphylactic;
  • ntshiab ntshav mob;
  • npaws.

Cuam tshuam rau lub peev xwm los tswj cov tshuab

Lub cuab yeej tuaj yeem cuam tshuam qhov kev nkag siab ntawm cov mloog thiab cov tshuaj tiv thaiv tus nqi tsuas yog thaum qhov tsos pom tsis xav ua los ntawm cov leeg hlwb. Hauv cov xwm txheej zoo li no, koj yuav tsum tau txwv cov sijhawm uas tsav tsheb thiab ua haujlwm nrog cov haujlwm.

Aterocardium tuaj yeem ua rau kub taub hau.

Cov lus qhia tshwj xeeb

Siv rau lub sijhawm qub

Thaum tsis muaj contraindications rau siv rau cov neeg muaj hnub nyoog 75 xyoos, lawv txoj kev kho yog nqa tawm raws li cov txheej txheem ib yam li hauv cov neeg mob noj qab haus huv hnub nyoog qis dua lub hnub nyoog no.

Tshuaj Aterocardium rau menyuam yaus

Cov tshuaj tsis yog npaj rau kev kho mob ntawm pawg neeg no. Qhov xaiv ntawm cov paum me nyuam tsis muaj kev tiv thaiv zoo yog pom zoo.

Siv thaum cev xeeb tub thiab lactation

Kev kawm txog cov nyhuv ntawm Aterocardium rau pawg no ntawm cov neeg mob tsis tau ua. Txhawm rau kom muaj kev nyab xeeb ntawm tus menyuam, nws tsis pom zoo kom sau cov tshuaj rau cov poj niam cev xeeb tub.

Cov kev tshawb fawb tsiaj qhia tias tseem muaj peev xwm nkag mus ntawm cov tshuaj txuam nrog rau niam mis. Yog tias nws yog qhov tsim nyog los sau tshuaj rau lactating poj niam, nws raug nquahu kom hloov tus menyuam mus rau kev pub mis.

Daim ntawv thov rau lub raum khiav tsis zoo

Cov ntaub ntawv hais txog kev siv tshuaj rau kev kho mob ntawm cov neeg mob uas tsis muaj txiaj ntsig ntawm kev ua haujlwm ntawm cov khoom siv no muaj tsawg. Kev ceev faj yuav tsum tau siv thaum kev sau tshuaj thiab thaum kho tshuaj. Nws raug nquahu tias cov ntsuas ntawm lub raum ua haujlwm yuav raug saib xyuas thaum muaj qhov tshwm sim tsis zoo los ntawm lub siab.

Cov ntaub ntawv ntawm kev siv cov tshuaj rau kev kho mob ntawm cov neeg mob raum tsis ua haujlwm tau txwv.

Siv rau lub siab ua haujlwm tsis zoo

Kev tsis txaus ntseeg ntawm hepatic muaj nuj nqi yog qhov tsis muaj tseeb rau kev teem caij ntawm Aterocardium. Muaj qee cov xwm txheej tsis hnyav, kev ceev faj yog qhia thaum lub sijhawm siv.

Aterocardial Tshem Tawm

Nrog kev noj tshuaj ntau dhau, muaj kev pheej hmoo los ntshav. Kev tshem tawm cov tsos mob ntawm tus mob no yog ua tau nrog kev pab ntawm platelet hloov ntshav. Qhov no yuav pab ua kom cov ntshav coagulation muaj nuj nqi ua ntej hloov kho cov lus sib xyaw ntawm cov qe ntshav.

Kev cuam tshuam nrog lwm yam tshuaj

Contraindicated kev sib txuas ua ke

Tsis muaj tshuaj pom tau tias nws siv nrog clopidogrel yuav ua rau txoj kev txhim kho kev phom sij ntawm lub neej.

Tsis pom zoo kev sib txuas ua ke

Qhov ncauj anticoagulants yuav ua rau kom ntshav los ntau ntxiv nrog clopidogrel.

Nws tsis pom zoo rau kev sib xyaw ua ke ntawm kev siv cov tshuaj no nrog kev siv tshuaj tiv thaiv ntawm cytochrome P450 isoenzymes.

Nws tsis pom zoo rau kev sib xyaw ua ke ntawm kev siv cov tshuaj no nrog kev siv tshuaj tiv thaiv ntawm cytochrome P450 isoenzymes.

Tej kev sib txuam uas xav tau ceev faj

Nrog kev sib xyaw ntawm cov tshuaj no nrog Omeprazole, Fluconazole, Carbamazepine, qhov kev ua ntawm isoenzymes koom nrog hauv kev hloov pauv hauv cov khoom noj ntawm clopidogrel yog txo qis. Xws li kev sib txuas ua ke tuaj yeem ua rau txo qis ntawm kev ua tau zoo ntawm Aterocardium hauv cov ntshav ntshav.

Kev ceev faj yuav tsum tau siv thaum siv Heparin, cyclooxygenase inhibitors, tsis siv tshuaj los tiv thaiv kev tsis haum tshuaj.

Cawv tau zoo

Tsis muaj ntaub ntawv hais txog kev cuam tshuam ntawm cawv ntawm qhov kev ua si pharmacological ntawm cov tshuaj. Nws tsis pom zoo rau haus dej cawv rau cov kab mob plawv, rau kev kho tus twg clopidogrel yog txwv.

Analogs

Cov qauv ntawm cov cuab yeej no yog:

  • Avxwv;
  • Ua Cuam;
  • Gridoklein;
  • Deplatt;
  • Sylt;
  • Claudia
  • Clopix;
  • Clorelo;
  • Lopigrol;
  • Oneklapse;
  • Kev Plagril;
  • Tessiron;
  • Pob Tsuas
Clopidogrel
Clopidogrel
Sylt
Plug

Cov ntsiab lus ntawm lub tsev muag tshuaj tawm

Kuv puas yuav tau yam tsis muaj daim ntawv yuav tshuaj?

Cov tshuaj muaj nyob ntawm cov tshuaj.

Atherocard nqi

Tus nqi ntawm Aterocardium hauv Ukraine yog 25 UAH rau 10 ntsiav tshuaj, 120 UAH rau 70 ntsiav tshuaj.

Cia rau cov neeg mob rau cov tshuaj

Yuav tsum muab ceev cia hauv qhov kub txog + 25 ° C.

Hnub tas sij hawm

Tsim nyog siv nyob rau hauv 3 xyoos txij li hnub tso.

Chaw tsim tshuaj paus

PJSC "Kiev Vitamin Cog".

Deplatt suav tias yog ib qho tshuaj analogue ntawm cov tshuaj Aterocard.
Qee zaus Zilt tawm tau hloov siv tshuaj Aterocardium.
Lopigrol raug suav tias yog ib qho tshuaj noj tshuaj ntawm Aterocard tshuaj.
Plagril yog ib qho tshuaj tiv thaiv ntawm cov tshuaj Aterocardium.
Aterocardium analogue - Cov tshuaj Agrel.

Kev tshuaj xyuas rau Atherocard

Stanislav Kaverin, kws kho plawv, Kiev.

Cov cuab yeej no pab cov neeg mob uas xav tau txo qis kev sib sau ua ke ntawm cov ntshav. Kuv muab nws rau cov neeg uas muaj tus mob myocardial infarction, mob atherothrombosis. Qhov zoo ntawm cov tshuaj yog tias nws tuaj yeem kho rau tus neeg laus. Ceev faj yuav tsum tau pom nyob rau hauv cov mob thaum tus neeg mob tiv thaiv los ntawm kev ua tsis taus lub raum.

Nws yog ib qho tseem ceeb thaum kev kho mob ua raws li cov lus qhia ntawm kws kho mob. Yog li kev kho yuav dhau yam tsis muaj teeb meem thiab yuav zoo li sai tau.

Maria Spivak, kws kho plawv, Zaporozhye.

Clopidogrel yog ib qho kev kho mob zoo uas pab sai sai txo cov ntshav platelet. Yog tias koj mus cuag txoj kev kho kom zoo, nws tuaj yeem siv los tiv thaiv ntau yam kab mob. Kuv tsis xav pom zoo tshuaj rau tus kheej, vim tias qhov no yog qhov txaus ntshai.

Cov tshuaj yuav tsim kev pheej hmoo los ntshav. Qhov no tshwm sim thaum kev pom zoo ntau npaum. Ib qho zoo li no tuaj yeem pom tom qab kev phais. Yuav cov tshuaj los ntawm cov tshuaj noj thiab noj nws nkaus xwb raws li cov lus qhia.

Denis, 59 xyoo, Donetsk.

Kuv sim coj clopidogrel tom qab myocardial infarction. Nws tau ntawv pov thawj los ntawm kws kho mob, yog li nws tswj hwm txhua qhov ntau npaum li cas thiab kev kho mob ntev li cas.

Ob peb hnub tom qab pib kho, Kuv ntsib cov kev mob tshwm sim. Lawv tau pib tsim txom cov neeg hauv lub qhov ntswg. Kuv mus txog tsev kho mob. Kev kuaj ntshav tau ua uas pom tias hemoglobin poob qis. Thaum xub thawj, cov kws kho mob sau ntawv txhua yam, tab sis tom qab ntuav koom nrog cov tsos mob. Muaj tus admixture ntawm cov ntshav hauv nws. Lawv tau ua txoj hnyuv siab uas lawv pom muaj qhov mob txhab. Kuv yuav tsum tau tseg tsis noj cov nyiaj.

Boris, 62 xyoo, Dnipro.

Kuv tau ntev los lawm ntawm arrhythmia, uas yog maj mam hlob. Tsis ntev los no, thaum lub sijhawm teem sijhawm tom ntej nrog kws kho plawv, Kuv raug kuaj mob atrial fibrillation. Txij li thaum kuv tau siv los ua ib qho ultrasound ntawm cov hlab ntsha ntawm cov hlab ntsha uas pom cov quav hniav uas pom, tus kws kho mob tau hais tias clopidogrel tiv thaiv platelet adhesion. Nws tau hais tias nws muaj peev xwm tiv thaiv qhov sib cais ntawm cov quav hniav uas tuaj yeem nkag mus rau lub ntsws thiab lwm yam kabmob los ntawm txhaws lub nkoj nyob ntawd thiab ua rau lub plawv nres.

Kuv tau noj cov tshuaj rau lub hlis thib ob. Muaj kev tsis txaus siab txog tam sim no. Kuv haus ob peb lwm yam tshuaj los tswj kuv lub plawv dhia. Kuv tsis pom tias muaj kev mob tshwm sim.

Julia, 67 xyoo, Kiev.

Kuv noj cov tshuaj no tom qab lub plawv nres. Thaum kho, Kuv ntsib cov kev tsis haum siab, tab sis txuas ntxiv kom noj.Cov kev kho mob tau kav ntau tshaj ib hlis. Muaj cem quav, mob plab. Tab sis cov tsos mob tsis loj heev. Lub plawv huv tseem ceeb dua.

Kuv thov ua tsaug rau cov cuab yeej no uas pab ua kom rov qab zoo li qub. Tam sim no kuv maj mam nkag mus cov yav dhau los cov lus sib dhos, txav mus, ua kev tawm dag zog. Leej twg paub li cas nws yuav xaus tsis muaj txoj kev kho mob.

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