Gabagamma belongs rau cov pab pawg ntawm cov tshuaj tiv thaiv kev puas hlwb. Lub hauv paus yog cov tshuaj nquag gabapentin, uas muaj cov nyhuv anticonvulsant. Tsis zoo li lwm cov tshuaj uas muaj cov nyhuv zoo sib xws, Gabagamma tsiav tshuaj tsis cuam tshuam rau cov metabolism ntawm gamma-aminobutyric acid. Hauv kev ua haujlwm hauv kev kho mob, cov tshuaj yeeb yaj kiab raug tso cai rau siv los ntawm cov neeg mob uas muaj hnub nyoog 12 xyoos txhawm rau tshem tawm qee qhov qaug dab peg, txij li 18 xyoo - rau kev kho mob ntawm neuropathic mob.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Gabapentin.
Gabagamma belongs rau cov pab pawg ntawm cov tshuaj tiv thaiv kev puas hlwb.
ATX
N03AX12.
Tso cov ntawv thiab cov nyob ua ke
Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm tsiav tshuaj, coated nrog ib tug nyuaj gelatin plhaub, rau kev tswj hwm qhov ncauj.
Cov tshuaj ntsiav
Cov haujlwm hauv cov tshuaj muaj 100, 300 lossis 400 mg ntawm cov tshuaj nquag ntawm gabapentin. Raws li cov khoom siv ntxiv rau kev tsim cov plhaub sab nraud yog siv:
- talc;
- mis nyuj qab zib;
- pob kws nplej siab;
- titanium dioxide.
Nyob ntawm seb ntau npaum li cas, cov tshuaj ntsiav tau txawv los ntawm cov xim: hauv qhov muaj 100 mg ntawm gabapentin, cov kua roj gelatin tseem dawb, ntawm 200 mg nws yog daj vim xim los ntawm cov hlau oxide, 300 mg yog txiv kab ntxwv. Sab hauv cov tsiav tshuaj yog hmoov dawb.
Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm tsiav tshuaj, coated nrog ib tug nyuaj gelatin plhaub, rau kev tswj hwm qhov ncauj.
Daim ntawv tsis muaj
Cov tshuaj tsis yog tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj.
Pharmacological kev txiav txim
Cov qauv hauv tshuaj lom neeg ntawm gabapentin yuav luag zoo tib yam rau cov neurotransmitters GABA (gamma-aminobutyric acid), tab sis cov tshuaj sib txuam ntawm Gabagamma yog tus cwj pwm ntawm cov yam ntxwv pharmacological. Cov tshuaj muaj tshuaj tsis cuam tshuam nrog aminalon raws li lwm cov tshuaj (barbiturates, derivatives ntawm GABA, Valproate) thiab tsis muaj GABA-ergic zoo. Gabapentin tsis cuam tshuam rau qhov rhuav tshem thiab kev siv of-aminobutyric acid.
Hauv cov kev tshawb fawb soj ntsuam, nws tau tshaj tawm tias cov tshuaj ua kom sib haum rau cov tes dej num hauv qab ntu ntawm calcium calcium, vim qhov kev ntws ntawm calcium ions tsawg dua. Nyob rau hauv lem, Ca2 + plays lub luag haujlwm tseem ceeb hauv kev tsim cov mob neuropathic. Hauv kev sib txuam nrog kev txwv tsis pub muaj cov calcium calcium, gabapentin tiv thaiv qhov khi ntawm glutamic acid rau neurons, kom lub paj hlwb ntawm lub cev tuag tsis tshwm sim. Kev tsim tawm ntawm GABA nce ntxiv, qhov kev tso tawm ntawm neurotransmitters ntawm pawg monoamine poob qis dua.
Nrog kev tswj hwm ntawm qhov ncauj, lub plhaub sab nraud pib tawg hauv qab qhov kev ua ntawm cov hnyuv enzymes, thiab gabapentin raug tso tawm hauv qhov chaw ze ntawm txoj hnyuv me.
Cov Tshuaj Pharmacokinetics
Nrog kev tswj hwm ntawm qhov ncauj, lub plhaub sab nraud pib tawg hauv qab qhov kev ua ntawm cov hnyuv enzymes, thiab gabapentin raug tso tawm hauv qhov chaw ze ntawm txoj hnyuv me. Cov tshuaj nquag raug ntes los ntawm microvilli. Gabapentin nkag mus rau hauv cov hlab ntshav, qhov twg nws nce mus txog qhov siab tshaj plaws ntshav ntshav hauv 2-3 teev. Nws yog ib qho tseem ceeb kom nco ntsoov tias kev siv bioavailability txo qis nrog kev noj ntau dua thiab nce mus txog qhov nruab nrab ntawm 60%. Noj mov tsis cuam tshuam rau kev ua tiav thiab kev nqus ntawm cov tshuaj.
Qhov kev tshem tawm ib nrab-lub neej ua rau 5-7 teev. Cov tshuaj nce mus txog qhov muaj zog sib luag nrog ib koob tshuaj. Qib ntawm kev khi ntawm gabapentin rau cov ntshav plasma protein tsawg - tsawg dua 3%, yog li cov tshuaj no tau faib rau hauv cov ntaub so ntswg hauv ib daim ntawv hloov pauv. Cov tshuaj yog txau siv lub qhov tso zis hauv nws daim ntawv qub, tsis tas yuav hloov pauv ntawm hepatocytes.
Dab tsi kho
Cov tshuaj yog zwm rau pab pawg ntawm cov tshuaj tiv thaiv kev ntxhov siab. Rau cov neeg mob uas muaj 12 xyoos rov hauv, Gabagamm yog qhov kev kho mob los ntawm ib qho kev sib koom ua ke tawm tsam ib nrab ntawm qaug dab peg, tus cwj pwm pom los ntawm qhov muaj lossis tsis muaj qhov dav dav thib ob. Rau cov neeg laus, cov ntsiav tshuaj tau muab tshuaj rau postherpetic neuralgia thiab tsos mob mob tiv thaiv keeb kwm ntawm tus mob ntshav qab zib neuropathy.
Rau cov neeg mob uas muaj hnub nyoog laus dua 12 xyoos, Gabagamm raug kho raws li ib feem ntawm txoj kev kho ua ke tawm tsam ib nrab ntawm chua leeg.
Cov Yuav Tsum Muaj
Cov tshuaj tsis tuaj yeem sau tseg yog tias muaj kev cuam tshuam ntau ntxiv ntawm tus neeg mob cov ntaub so ntswg mus rau cov txheej txheem yam ntxwv ntawm Gabagamma. Vim tias muaj cov lactose hauv cov tshuaj muaj pes tsawg leeg, cov tshuaj yog contraindicated rau kev siv rau cov neeg mob uas muaj keeb tiv thaiv tsis muaj mis nyuj tsis muaj piam thaj thiab galactose, nrog tsis muaj lactase thiab malabsorption ntawm monosaccharides.
Nrog saib xyuas
Nws tsis pom zoo lossis ceev faj yuav tsum tau siv thaum coj tus neeg mob nrog cov kab mob ntawm lub siab lub ntsws lossis lub raum tsis ua haujlwm.
Yuav ua li cas coj Gabagamma
Cov tshuaj yog noj ntawm qhov ncauj, tsis hais txog ntawm cov zaub mov noj. Yog tias koj xav tso tseg cov tshuaj, koj yuav tsum tsum tsis txhob siv Gabagamma maj mam dhau ib lub lim tiam. Kev siv tshuaj kho mob nrog kev nce ntxiv hauv qhov ntau yog ua tiav thaum tus neeg mob qaug zog, lub cev nyhav los yog mob hnyav ntawm tus neeg mob, suav nrog kev qaug zog hauv lub sijhawm rov kho dua tom qab hloov chaw. Thaum zoo li no, nws yog ib qho tsim nyog yuav tsum pib nrog kev noj ntau npaum li 100 mg.
Kev kho qhov tseeb yog tsim los ntawm tus kws kho mob nyob ntawm seb tus neeg mob li cas thiab kev saib duab ntawm lub pathology.
| Tus kab mob | Txoj kev kho tus qauv |
| Neuropathic mob hauv cov neeg mob cov neeg laus | Qhov tshuaj txhua hnub nyob rau theem pib ntawm kev kho mob ncav cuag 900 mg nrog rau kev tswj hwm ib zaug 3 zaug ib hnub. Yog tias tsim nyog, qhov niaj hnub niaj hnub tuaj yeem nce ntxiv mus txog qhov ntau ntawm 3600 mg. Nws raug nquahu kom pib kho yam tsis txo qhov hno raws li cov qauv txheej txheem: 300 mg 3 zaug ib hnub. Hauv qhov no, cov neeg mob uas lub cev tsis muaj zog txaus yuav tsum nce kev noj tshuaj txhua hnub rau 900 mg rau 3 hnub raws li lwm txoj kev kho mob:
|
| Ib nrab ntawm cov neeg nriaj nqaij hauv cov neeg muaj 12 xyoos rov saud | Nws raug nquahu kom noj li ntawm 900 rau 3600 mg ib hnub. Kev siv tshuaj kho mob rau thawj hnub pib nrog kev noj tshuaj ntawm 900 mg, muab faib ua 3 koob tshuaj. Txo txoj kev pheej hmoo ntawm cov leeg mob, qhov luv nruab nrab ntawm kev txhaj tshuaj txwv tsis pub dhau 12 teev. Hauv cov hnub tom qab kev kho mob, nws yog qhov ua tau kom nce qhov koob tshuaj kom ntau (3.6 g). |
Nrog ntshav qab zib
Cov tshuaj tsis cuam tshuam rau cov ntshav qab zib plasma qib thiab tsis hloov pauv kev noj tshuaj insulin los ntawm beta cov kab mob ntawm cov kua txiav, yog li tsis tas yuav txiav tawm ntawm cov kev kho mob uas tau pom zoo nyob rau hauv muaj ntshav qab zib mellitus.
Sab sij huam
Cov kev mob tshwm sim rau feem ntau tshwm sim nrog kev xaiv cov tshuaj tsis zoo los yog tsis zoo los ntawm cov lus pom zoo kho mob. Tej zaum qhov kev txhim kho ntawm kev haus tshuaj kub taub hau, nce tawm hws, mob hauv ntau qhov chaw ntawm lub cev.
Los ntawm cov leeg nqaij thiab pob txha sib txuas
Cov tshuaj tsis cuam tshuam rau cov leeg mus ntawm lub cev, tab sis nrog kev puas tsuaj rau ntawm cov leeg hlwb, mob ntawm cov leeg thiab cov pob qij txha, nce pob txha hauv plab tuaj yeem tshwm sim.
Hematopoietic plab hnyuv siab raum
Nrog rau kev hloov pauv ntawm qhov tsis muaj ntawm cov ntshav hematopoietic, thrombocytopenic purpura yuav tshwm sim, nrog rau bruising, txo qis hauv cov naj npawb ntawm cov khoom tsim hauv cov ntshav.
Kev kho mob txoj hnyuv
Cov kev tsis zoo tshwm sim hauv cov zom zaub yog cov yam ntxwv hauv qab no:
- mob epigastric;
- anorexia;
- flatulence, raws plab, ntuav;
- o ntawm daim siab;
- nce kev ua si ntawm hepatocytic aminotransferases;
- daj ntseg tiv thaiv keeb kwm ntawm hyperbilirubinemia;
- pancreatitis
- dyspepsia thiab qhov ncauj qhuav.
Nruab nrab hauv lub paj hlwb
Nrog inhibition ntawm lub paj hlwb, nws yog qhov ua tau:
- Kiv taub hau
- ua txhaum txoj cai ntawm kev hloov chaw;
- mob caj dab;
- poob ntawm reflexes;
- ua kom pom tseeb;
- kev ploj kev tswj kev xav hauv lub siab;
- tsis tshua muaj kev txawj ntse ua haujlwm, kev xav tsis meej;
- paresthesia.
Muaj qee zaus, mob amnesia kev loj hlob, qhov zaus ntawm qaug dab peg qaug dab peg ntau ntxiv.
Los ntawm lub tshuab ua pa
Tej zaum kev tsim kho txog siav siav, mob ntsws. Nrog kev tiv thaiv kab mob tsis muaj zog, kev ua kis kab mob, kab mob khaub thuas, kab mob pharyngitis, thiab mob ntswg tuaj yeem tsim kho.
Ntawm ib sab ntawm daim tawv nqaij
Hauv qee kis tshwj xeeb, mob ntxau, ntxig kab mob, mob erythema, khaus thiab tawm pob tuaj yeem tshwm sim.
Los ntawm genitourinary system
Muaj qee zaus, cov neeg mob ntxim yuav muaj lub peev xwm mob txeeb zig, mob erections ntaug tsawg, enuresis (tso zis tsis ua haujlwm), thiab mob raum tsis ua haujlwm.
Muaj qee zaus, cov neeg mob ntxim yuav muaj lub peev xwm ua mob txeeb zig.
Los ntawm cov hlab plawv system
Tej zaum qhov kev txhim kho ntawm cov paib vasodilation, nce siab hauv lub plawv thiab nce ntshav siab.
Kev ua xua
Yog tias tus neeg mob tau ntxim rau muaj kev phiv tshuaj, nws muaj peev xwm tsim Quincke edema, anaphylactic shock, angioedema, Stevens-Johnson syndrome thiab tawv nqaij ua pob.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Txhawm rau saib xyuas qhov muaj kev pheej hmoo tsis zoo nyob rau hauv lub hauv nruab nrab lub paj hlwb (CNS) thaum lub sijhawm tshuaj kho mob, nws raug nquahu kom txwv tsis pub ua haujlwm nrog cov khoom phom sij lossis cov khoom siv tsis zoo, tsav tsheb thiab koom nrog kev ua si uas yuav tsum muaj kev xav thiab ceev ntawm cov tshuaj tiv thaiv los ntawm tus neeg mob.
Cov lus qhia tshwj xeeb
Txawm hais tias tsis muaj qhov tsos mob tawm thaum lub sij hawm siv tshuaj kho nrog gabapentin, nws muaj kev pheej hmoo ntawm kev rov ua dua ntawm cov leeg mob hauv cov neeg mob uas muaj ib feem ntawm qhov kev ntxim nyiam. Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias cov tshuaj no tsis yog qhov txiaj ntsig zoo tiv thaiv kev tawm tsam tus mob vwm vwm.
Nrog rau kev kho ua ke nrog Morphine, nws yog qhov yuav tsum tau nce ntxiv cov tshuaj ntawm Gabagamma tom qab sab laj nrog kws kho mob. Hauv qhov no, tus neeg mob yuav tsum ua raws li kev saib xyuas kev kho mob nruj kom tiv thaiv qhov pib ntawm cov tsos mob ntawm kev nyuaj siab ntawm lub hauv nruab nrab ntawm lub paj hlwb (tsaug zog). Nrog rau kev txhim kho cov cim ntawm kev cuam tshuam ntawm cov hlab ntsha tsis sib haum, nws yog qhov tsim nyog los txo cov ntau npaum ntawm ob cov tshuaj.
Nrog rau kev kho ua ke nrog Morphine, nws yog qhov yuav tsum tau nce ntxiv cov tshuaj ntawm Gabagamma tom qab sab laj nrog kws kho mob.
Hauv chav kawm ntawm kev kawm tshawb fawb, qhov cuav tsis zoo rau qhov muaj cov proteinuria tuaj yeem raug sau cia, yog li ntawd, thaum xaiv Gabagamma ua ke nrog lwm cov tshuaj tiv thaiv kab mob, nws yog qhov yuav tsum tau nug tus neeg ua haujlwm hauv chaw soj ntsuam ua qhov kev tshawb xyuas hauv ib txoj hauv kev tshwj xeeb rau precipitate sulfosalicylic acid.
Siv rau lub sijhawm qub
Cov neeg muaj hnub nyoog tshaj 60 xyoo tsis tas yuav kho qhov koob ntxiv.
Tshuaj Khawb Khauj Rau Cov Menyuam
Cov tshuaj tsis pom zoo rau cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 18 xyoo, tshwj tsis yog muaj qee leej neeg foob.
Siv thaum cev xeeb tub thiab lactation
Cov kev tshawb fawb soj ntsuam ntawm cov nyhuv ntawm cov tshuaj ntawm kev txhim kho embryonic tsis tau ua. Yog li no, gabapentin raug sam hwm rau cov poj niam cev xeeb tub tsuas yog muaj mob hnyav, thaum muaj txiaj ntsig zoo ntawm kev siv tshuaj lossis kev phom sij rau leej niam lub neej dhau qhov txaus ntshai ntawm kev cuam tshuam ntawm intrauterine ntawm tus me nyuam hauv plab.
Gabapentin raug samfwm rau cov pojniam xeebtub tsuas yog thaum muaj mob hnyav.
Cov tshuaj tseem ceeb tuaj yeem raug cais tawm hauv niam cov kua mis, yog li kev pub mis rau niam mis yuav tsum tau muab tso tseg thaum kho tshuaj.
Daim ntawv thov rau lub raum khiav tsis zoo
Hauv lub xub ntiag tsis ua haujlwm ntawm lub raum, qhov kev noj tshuaj ntau dua yog kho tau raws li creatinine qhov kev tshem tawm (Cl).
| Cl, ml / min | Cov koob tshuaj txhua hnub muab faib ua 3 koob |
| ntau dua 80 | 0.9-3.6 g |
| ntawm 50 txog 79 | 600-1800 mg |
| 30-49 | 0.3-0.9 g |
| los ntawm 15 txog 29 | 300 mg yog kho nrog thaj tsam ntawm 24 teev. |
| tsawg dua 15 |
Noj ntau dhau
Nrog kev tsim txom ntawm cov tshuaj vim yog ib zaug ntawm ib koob loj, cov cim qhia ntawm kev siv ntau dhau:
- Kiv taub hau
- pom kev ua haujlwm tsis pom tseeb los ntawm kev sib cais ntawm cov khoom;
- hais lus tsis meej;
- nkees;
- tsaug zog
- zawv plab
Muaj peev xwm ua tau nce los yog nce kev pheej hmoo ntawm lwm cov kev phiv tshuaj. Tus neeg raug tsim txom yuav tsum tau mus pw hauv tsev kho mob vim pais plab, muab tau tshuaj hnoos tau noj ntawm 4 teev dhau los. Txhua qhov tsos mob ntawm kev siv ntau dhau yog tshem tawm los ntawm kev kho tus mob. Hemodialysis siv tau.
Nrog kev noj ntau dhau ntawm cov tshuaj, kev qaug zog yuav tshwm sim.
Kev cuam tshuam nrog lwm yam tshuaj
Nrog rau thaum uas tig mus siv ntawm Gabagamma nrog lwm cov tshuaj, cov kev coj ua hauv qab no tshwm sim:
- Yog tias koj noj Morphine 2 teev ua ntej siv gabapentin, koj tuaj yeem nce qhov kev mloog ntxiv tom kawg yog 44%. Hauv qhov no, ib qho kev nce hauv qhov mob pib qhia. Tsis muaj cov chaw kho mob tseem ceeb tau tsim los.
- Ua ke nrog cov tshuaj antacids thiab kev npaj ua kom muaj ntsev thiab aluminium ntsev, kev siv bioavailability ntawm gabapentin yog txo 20%. Txhawm rau kom tsis txhob ua kom lub cev tsis muaj zog, nws raug nquahu kom noj cov tshuaj ntsiav Gabagamma tom qab 2 teev tom qab noj tshuaj antacids.
- Probenecid thiab cimetidine tsis txo qis nthuav dav thiab ntshav ntau ntawm cov tshuaj nquag.
- Phenytoin, tshuaj tiv thaiv qhov ncauj, phenobarbital thiab carbamazepine tsis cuam tshuam rau lub plasma cov ntsiab lus ntawm gabapentin.
Cawv tau zoo
Thaum lub sijhawm kho cov tshuaj, nws yog txwv tsis pub haus dej cawv. Ethanol nyob rau hauv muaj pes tsawg leeg haus dej haus cawv muaj qhov ua kom muaj zog tiv thaiv ntawm cov hlab ntsha hauv nruab nrab thiab ua rau muaj kev cuam tshuam ntau ntxiv.
Analogs
Cov analogues ntawm cov tshuaj muaj xws li:
- Katena
- Gabapentin;
- Neurontin;
- Tebantin;
- Convalis.
Hloov mus rau lwm cov tshuaj tau tso cai tsuas yog tom qab kev sab laj kho mob nrog qhov ua tau zoo ntawm Gabagamma lossis nrog qhov zoo li tsis zoo.
Ua piv txwv, koj tuaj yeem siv Neurontin.
Nyiaj so koobtsheej mob Gabagamma los ntawm lub tsev muag tshuaj
Cov tshuaj tsis raug muag yam tsis muaj daim ntawv sau los ntawm kws kho mob.
Kuv tuaj yeem yuav yam tsis tas yuav tshuaj
Vim tias txoj kev pheej hmoo ntawm kev nyuaj siab ntau ntxiv rau ntawm lub hauv nruab nrab lub paj hlwb thiab cov tsos tshwm sim tsis zoo los ntawm lwm qhov hauv nruab nrog cev, qhov muag dawb ntawm Gabagamma yog tsawg.
Tus nqi Gabagamma
Tus nqi nruab nrab ntawm cov tshuaj txawv ntawm 400 rau 1150 rubles.
Cia rau cov neeg mob rau cov tshuaj
Nws raug nquahu kom khaws cov tshuaj anticonvulsant ntawm qhov kub txog + 25 ° C hauv qhov chaw txias nrog qhov av noo tsawg.
Hnub tas sij hawm
3 xyoos
Tus tsim khoom gagagamma
Werwag Pharma GmbH & Co. KG, Lub Tebchaws Yelemees.
Nws raug nquahu kom khaws cov tshuaj anticonvulsant ntawm qhov kub txog + 25 ° C hauv qhov chaw txias nrog qhov av noo tsawg.
Kev txheeb xyuas rau ntawm Gabagamma
Izolda Veselova, 39 xyoos, St. Petersburg
Cov tshuaj ntsiav Gabagamma raug txiav tawm hauv kev sib txuas nrog neuralgia 2 ceg ntoo. Tus kws kho mob tau hais tias ntau npaum li cas tau teev cia nyob ntawm qhov ntsuas ntawm qhov tshwm sim zoo. Hauv kuv qhov xwmtxheej, Kuv yuav tsum tau noj 6 txog tshuaj ntsuab ib hnub. Nws yuav tsum tau ua nyob rau hauv kev nce zuj zus: thaum pib ntawm txoj kev kho, nws pib nrog 1-2 tsiav tshuaj rau 7 hnub, tom qab uas qhov tshuaj tau nce ntxiv. Kuv xav txog nws txoj kev hais daws rau qhov pom zoo. Kuv tsis pom tias muaj kev phiv thaum kho. Cov cramps nres.
Dominika Tikhonova, 34 xyoo, Rostov-on-Don
Nws coj Gabagamma raws li kws kho mob neurologist cuam tshuam nrog trigeminal neuropathy. Carbamazepine yog qhov tsis muaj txiaj ntsig hauv kuv qhov xwm txheej. Lub kaus poom pab nrog cov thawj ntxias. Lub sij hawm ntawm txoj kev kho cov tshuaj tau kav 3 lub hlis txij lub Tsib Hlis 2015. Txawm hais tias tus mob ntev los, qhov mob thiab cov tsos mob ntawm tus kab mob pathology tau dhau los.Qhov tsuas yog drawback yog tus nqi. Rau 25 tsiav tshuaj Kuv yuav tsum them 1200 rubles.
